I think I have mentioned before, but I have genetic high cholesterol (unmedicated, it's in the 300's). Several years ago, my lipidologist put me on an injectable med called Repatha. It's an every two week shot you self-administer (kind of like an EpiPen).
That, in combination with a low dose statin, has my total cholesterol in the 90's, and my LDL at 21.